Synthesis of new N-analogous corollosporine derivatives with antibacterial activity by laccase-catalyzed amination.
نویسندگان
چکیده
Corollosporine isolated from the marine fungus Corollospora maritima and N-analogous corollosporines are antimicrobial substances. Owing to the basic structure of the N-analogous corollosporines, they have become an attractive target for laccase-catalyzed derivatisation. In this regard we report on the straightforward laccase-catalyzed amination of dihydroxylated arenes with N-analogous corollosporines. In biological assays the obtained amination products are more active than the parent compounds.
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ورودعنوان ژورنال:
- Chemical & pharmaceutical bulletin
دوره 56 6 شماره
صفحات -
تاریخ انتشار 2008